Research Associates

Susana G. Sotocinal
Jean-Sebastien Austin

Postdoctoral Fellows

Robert E. Sorge
Loren J. Martin

Graduate Students

Alexander H. Tuttle
Jeffrey Wieskopf

Undergraduate Student Assistants


 
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Susana G. Sotocinal, M.S.
2002-present

Director of Genomics
  • Mogil, J.S., Miermeister, F., Seifert, F., Strasburg, K., Zimmermann, K., Reinold, H., Austin, J.-S., Bernardini, N., Chesler, E.J., Hofmann, H.A., Hordo, C., Messlinger, K., Nemmani, K.V., Rankin, A.L., Ritchie, J., Siegling, A., Smith, S.B., Sotocinal, S.G., Vater, A., Lehto, S.G., Klussmann, S., Quirion, R., Michaelis, M., Devor, M., and Reeh, P.W.  Variable sensitivity to noxious heat is mediated by differential expression of the CGRP gene. Proc. Natl. Acad. Sci., U.S.A., 102:12938-12943, 2005.
  • Langford, D.J., Crager, S.E., Shehzad, Z., Smith, S.B., Sotocinal, S.G., Levenstadt, J.S., Chanda, M.L., Levitin, D.J., and Mogil, J.S.  Social modulation of pain as evidence for empathy in mice.  Science, 312:1967-1970, 2006.
  • Mogil, J.S., Ritchie, J., Sotocinal, S.G., Smith, S.B., Croteau, S., Levitin, D.J., and Naumova, A.K.  Screening for pain phenotypes: analysis of three congenic mouse strains on a battery of nine nociceptive assays.  Pain, 126:24-34, 2006.
  • Smith, S.B., Marker, C.L., Perry, C., Liao, G., Sotocinal, S.G., Austin, J.-S., Melmed, K., Clark, D.J., Peltz, G., Wickman, K., and Mogil, J.S.  Quantitative trait locus and computational mapping identifies Kcnj9 (GIRK3) as a candidate gene affecting analgesia from multiple drug classes. Pharmacogenet. Genom.,18:231-242, 2008.
  • LaCroix-Fralish, M.L., Mo, G., Smith, S.B., Sotocinal, S.G., Ritchie, J., Austin, J.-S., Melmed, K., Schorscher-Petcu, A., Laferriere, A., Lee, T.H., Romanovsky, D., Liao, G., Behlke, M.A., Clark, J.D., Peltz, G., Seguela, P., Dobretsov, M., and Mogil, J.S.  The beta3 subunit of the Na+,K+-ATPase mediates variable nociceptive sensitivity in the formalin test.  Pain, 144:294-302, 2009.
  • Langford, D.J., Tuttle, A.H., Brown, K., Deschenes, S., Fischer, D.B., Mutso, A., Root, K.C., Sotocinal, S.G., Stern, M.A., Mogil, J.S., and Sternberg, W.F.  Social approach to pain in laboratory mice.  Soc. Neurosci., 5:163-170, 2010.
  • Langford, D.J., Bailey, A.L., Chanda, M.L., Clarke, S.E., Drummond, T.E., Echols, S., Glick, S., Ingrao, J., Klassen-Ross, T., LaCroix-Fralish, M.L., Matsumiya, L., Sorge, R.E., Sotocinal, S.G., Tabaka, J.M., Wong, D., van den Maagdenberg, A.M.J.M., Ferrari, M.D., Craig, K.D., and Mogil, J.S. Coding of facial expression of pain in the laboratory mouse.  Nat. Meth., 7:447-449, 2010.
  • Schorscher-Petcu, A., Sotocinal, S.G., Ciura, S., Dupre, A., Ritchie, J., Sorge, R.E., Crawley, J.N., Hu, S.-B., Nishimori, K., Young, L.J., Tribollet, E., Quirion, R., and Mogil, J.S. Oxytocin-induced analgesia and scratching are mediated by the vasopressin-1A receptor in the mouse.  J. Neurosci., 30:8274-8284, 2010.
  • Fortin, A., Diez, E., Ritchie, J., Sotocinal, S.G., Dube, M.-P., Gagne, M., Paquette, O., Skamene, E., and Mogil, J.S. Positional cloning of a quantitative trait locus contributing to pain sensitivity: possible mediation by Tyrp1 (tyrosinase-related protein 1).  Genes Brain Behav., 9:856-867, 2010.
  • Sotocinal, S.G., Sorge, R.E., Zaloum, A., Tuttle, A.H., Martin, L.J., Wieskopf, J.S., Mapplebeck, J.C.S., Wei, P., Zhan, S., Zhang, S., McDougall, J.J., King, O.D., and Mogil, J.S.  The Rat Grimace Scale: a partially automated method for quantifying pain in the laboratory rat via facial expressions.  Mol. Pain, 7:55, 2011.
  • Matsumiya, L.C., Sorge, R.E., Sotocinal, S.G., Tabaka, J.M., Wieskopf, J.S., Zaloum, A., King, O.D., and Mogil, J.S.  Using the Mouse Grimace Scale to reevaluate the efficacy of postoperative analgesics in laboratory mice. J. Am. Assoc. Lab. Anim. Sci., in press.
  • Matsumiya, L.C., Sorge, R.E., Sotocinal, S.G., Tabaka, J.M., Wieskopf, J.S., Zaloum, A., King, O.D., and Mogil, J.S.  Using the Mouse Grimace Scale to reevaluate the efficacy of postoperative analgesics in laboratory mice. J. Am. Assoc. Lab. Anim. Sci., in press.
  • Matsumiya, L.C., Sorge, R.E., Sotocinal, S.G., Tabaka, J.M., Wieskopf, J.S., Zaloum, A., King, O.D., and Mogil, J.S.  Using the Mouse Grimace Scale to reevaluate the efficacy of postoperative analgesics in laboratory mice. J. Am. Assoc. Lab. Anim. Sci., in press.
  • Mogil, J.S., Sorge, R.E., LaCroix-Fralish, M.L., Smith, S.B., Fortin, A., Sotocinal, S.G., Ritchie, J.R., Austin, J.-S., Schorscher-Petcu, A., Melmed, K., Czerminski, J., Bittong, R.A., Mokris, J.B., Neubert, J.K., Campbell, C.M., Edwards, R.R., Campbell, J.N., Crawley, J.N., Lariviere, W.R., Wallace, M.R., Sternberg, W.F., Balaban, C.D., Belfer, I., and Fillingim, R.B. Pain sensitivity and vasopressin analgesia are mediated by a gene-sex-environment interaction. Nat. Neurosci., 14:1569-1573, 2011.
  • Sorge, R.E., LaCroix-Fralish, M.L., Tuttle, A.H., Sotocinal, S.G., Austin, J.-S., Ritchie, J., Chanda, M.L., Graham, A.C., Topham, L., Beggs, S., Salter, M.W., and Mogil, J.S.  Spinal cord Toll-like receptor 4 mediates inflammatory and neuropathic hypersensitivity in male but not female mice.  J. Neurosci., 31:15450-15454, 2011.
  • Shekarabi, M., Moldrich, R., Rasheed, S., Salin-Cantegrel, A., Laganiere, J., Rochesfort, D., Hince, P., Huot, K., Gaudet, R., Kurniawan, N., Sotocinal, S.G., Ritchie, J., Dion, P., Mogil, J.S., Richards, L., and Rouleau, G. Loss of neuronal potassium/chloride cotransporter 3 (KCC3) is responsible for the degenerative phenotype in a conditional mouse model of hereditary motor and sensory neuropathy associated with agenesis of the corpus callosum. J. Neurosci., in press. 
  • Malfait, A.M., Seymour, A.B., Gao, F., Tortorella, M.D., Hellio Le Graverand-Gastineau, M.P., Wood, L.S., Doherty, M., Doherty, S., Zhang, W., Arden, N.K., Vaughn, F.L., Leaverton, P.E., Spector, T.D., Hart, D.J., Maciewicz, R.A., Muir, K.R., Das, R., Sorge, R.E., Sotocinal, S.G., Schorscher-Petcu, A., Valdes, A.M., and Mogil, J.S.  A role for PACE4 in osteoarthritis pain: evidence from human genetic association and null mutant phenotype.  Ann. Rheum. Dis., in press.